Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Identifieur interne : 005812 ( Main/Exploration ); précédent : 005811; suivant : 005813Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity
Auteurs : Camilla Norrmén [Finlande] ; Wouter Vandevelde [Belgique] ; Annelii Ny [Belgique] ; Pipsa Saharinen [Finlande] ; Massimiliano Gentile [Finlande] ; Guttorm Haraldsen [Norvège] ; Pauli Puolakkainen [Finlande] ; Eugene Lukanidin [Danemark] ; Mieke Dewerchin [Belgique] ; Kari Alitalo [Finlande] ; Tatiana V. Petrova [Finlande]Source :
- Blood [ 0006-4971 ] ; 2010.
Abstract
The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin β1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in
Url:
DOI: 10.1182/blood-2009-03-212274
PubMed: 19965622
PubMed Central: 2815506
Affiliations:
- Belgique, Danemark, Finlande, Norvège
- Hovedstaden, Uusimaa, Østlandet
- Copenhague, Helsinki, Oslo
- Université d'Helsinki
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Biology Program, Biomedicum Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Pathology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><affiliation wicri:level="1"><nlm:aff id="aff1">Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki, Finland;</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular and Cancer Biology Program, Biomedicum Helsinki, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The lymphatic vasculature is important for the regulation of tissue fluid homeostasis, immune response, and lipid absorption, and the development of in vitro models should allow for a better understanding of the mechanisms regulating lymphatic vascular growth, repair, and function. Here we report isolation and characterization of lymphatic endothelial cells from human intestine and show that intestinal lymphatic endothelial cells have a related but distinct gene expression profile from human dermal lymphatic endothelial cells. Furthermore, we identify liprin β1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, as highly expressed in intestinal lymphatic endothelial cells in vitro and lymphatic vasculature in vivo, and show that it plays an important role in the maintenance of lymphatic vessel integrity in <named-content content-type="genus-species">Xenopus</named-content> tadpoles.</p></div></front></TEI><affiliations><list><country><li>Belgique</li><li>Danemark</li><li>Finlande</li><li>Norvège</li></country><region><li>Hovedstaden</li><li>Uusimaa</li><li>Østlandet</li></region><settlement><li>Copenhague</li><li>Helsinki</li><li>Oslo</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><noRegion><name sortKey="Norrmen, Camilla" sort="Norrmen, Camilla" uniqKey="Norrmen C" first="Camilla" last="Norrmén">Camilla Norrmén</name></noRegion><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Gentile, Massimiliano" sort="Gentile, Massimiliano" uniqKey="Gentile M" first="Massimiliano" last="Gentile">Massimiliano Gentile</name><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><name sortKey="Puolakkainen, Pauli" sort="Puolakkainen, Pauli" uniqKey="Puolakkainen P" first="Pauli" last="Puolakkainen">Pauli Puolakkainen</name><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name></country><country name="Belgique"><noRegion><name sortKey="Vandevelde, Wouter" sort="Vandevelde, Wouter" uniqKey="Vandevelde W" first="Wouter" last="Vandevelde">Wouter Vandevelde</name></noRegion><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name><name sortKey="Ny, Annelii" sort="Ny, Annelii" uniqKey="Ny A" first="Annelii" last="Ny">Annelii Ny</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Haraldsen, Guttorm" sort="Haraldsen, Guttorm" uniqKey="Haraldsen G" first="Guttorm" last="Haraldsen">Guttorm Haraldsen</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Lukanidin, Eugene" sort="Lukanidin, Eugene" uniqKey="Lukanidin E" first="Eugene" last="Lukanidin">Eugene Lukanidin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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